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Questions & Answers

Heat Intolerance Caused By Disease Process

Suffering from the symptoms of a disease can strain a person's sanity - at least it did mine. Add to that the inability to go outdoors during summer because their body can no longer manage the heat, well that may just send them over the edge. 

My neurologist still can't tell me why Multiple Sclerosis causes heat intolerance, nor do I expect an answer any time soon. The fact that I am not alone is sad and comforting, but genuinely disheartening for all of us because someone is not doing their job and studying this problem.

The fact that numerous diseases cause issues with heat means that there are other people searching for solutions, and I hope the information provided here will provide some more information that may help someone.


Addison's Disease is a disorder where your body produces insufficient amounts of certain hormones produced by your adrenal glands. Treatment with corticosteroids may impair your ability to fall asleep. Keeping cool during the night may help.

Allergy Medications can inhibit your body's ability to cool itself by preventing sweating. Cooling therapy can help.

Anhidrosis is a  condition that prevents people from sweating. This increases the risk of  heat related illness such as heat exhaustion or heat stroke.

Autoimmune Diseases occur your immune system creates antibodies and immune cells that attack healthy tissue by mistake. Temperature control may be necessary.

Cystic Fibrosis is a genetic disease that causes persistent lung infections and limits the ability to breathe over time. It causes a thick, buildup of mucus in the lungs, pancreas, and other organs.

Dysautonomia is a condition causing malfunction of the autonomic nervous system (body functions you do not need to think about). This includes body temperature control.

Ectodermal Dysplasia is a genetic disorder that can affect development or function of sweat glands, hair, teeth and nails. This can inhibit perspiration causing heat related illness such as heat exhaustion or heat stroke.

Ehlers-Danlos syndrome is a connective tissue disorder affecting skin and joints.

Epilepsy is a neurological condition which affects the nervous system. Lowering the core body temperature may help decrease the likelihood of a seizure.

Fabry Disease results from abnormal deposits of a particular fatty substance (called globotriaosylcera-mide) in blood vessel walls throughout the body. Anhidrosis (lack of sweating) is a common symptom.

Graves' Disease is over-activity of the thyroid gland. Heat sensitivity and increased perspiration are common signs and symptoms of this disease.

Hereditary Sensory Autonomic Neuropathy is a term used to describe a disease which inhibits sensation.

Hyperhidrosis is a condition that causes excessive sweating. Compensatory sweating after sympathectomy may occur. Cooling the body may help as physicians have noticed that patients get better in the winter.

Ichthyosis is a skin disorders characterized by dry, scaling skin that may be thickened or very thin. Overheating can be one of numerous medical complications.  

Lupus is a chronic autoimmune disease that can damage any part of the body. Cooling can ease pain and stiffness.

Lyme Disease is a bacterial infection primarily transmitted by Ixodes ticks. Cooling therapy can help decrease the arthritic pain and stiffness associated with chronic lyme disease.

Medications can also cause heat intolerance where cooling therapy may be your answer. Medications include: antidepressants, antihistamines, amphetamines, anticholinergics, caffeine, pain relief medications, blood pressure medications, antipsychotics, diuretics, anti-parkinsonian drugs and alcohol.

Menopause is defined as the state of an absence of menstrual periods for 12 months. Hot flashes can be managed with cooling therapy.

Mitochondrial Disease is a disorder where the mitochondria of the cell fail to produce enough energy for cell or organ function. It is important to Maintain an ambient environmental temperature.

Multiple Sclerosis is a disease that disrupts the flow of information from the brain to the body. Heat can worsen MS symptoms.

Myasthenia Gravis is a neuromuscular disorder affecting skeletal muscles.

Nerve Damage may cause problems controlling your body temperature. Cooling therapy will help when you are unable to sweat.

Rheumatoid Arthritis is an autoimmune disease that causes chronic inflammation of the joints. Cold is best for acute pain. It can numb painful areas and reduce inflammation.

Sjögren's Syndrome is a disease affecting moisture-producing glands.

Wilson's Syndrome is related to thyroid dysfunction and people may suffer temperature sensation abnormalities. Cooling therapy will help when unable to tolerate heat.

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